Regulatory Role of Hfq. protein

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The interaction between the Hfq protein and single-stranded DNA reveals the role of the amyloid protein in genetic recombination and reproduction

Regulatory role of Hfq protein, a bacterial protein specifically found in Escherichia coli (Escherichia coli, also known as colibacillus or Escherichia coli, is a bacterium…), is mainly attributed to its function as an RNA chaperone that facilitates interactions between RNAs. That protein (A protein is a biological macromolecule composed of one or more…) It is also involved in the structuring and compression of DNA.

Extensive international collaboration has been studied through various techniques ofphotographer (Images are basically the making and distribution of physical images that…) and spectroscopy, in particular synchrotron (The term synchrotron refers to a large electromagnetic instrument designed to…)and compounds of the amyloid protein Hfq and single-stranded DNA. Thus, it is clear that the Hfq protein may play a role genetic recombination (Genetic recombination is “the phenomenon that leads to…) and repetition.

Hfq protein is a bacterial regulator involved in many aspects metabolism (Metabolism is the totality of molecular and biological transformations…) Nucleic acids (RNA and DNA) that give it many important physiological functions. Among these several functions, it is necessary to repeat them phage (A phage is a virus that only infects bacteria. In Greek, vaghton…) Qβ, RNA virus (An RNA virus is a virus that uses RNA as genetic material, otherwise…) Single-stranded positive that infects bacteria such as Escherichia coliAnd the bacteria (Bacteria (Bacteria) are prokaryotic protozoa, characterized by …) Community intestinal germs (Gut flora is the group of microorganisms present in the digestive system. …). hfq . protein Organize (Slates are alloys of tin or lead and antimony.) It also efficiently translates mRNA and helps compress double-stranded DNA in bacterial cells. But these functions need to be better explored and defined, especially patternsinteraction (An interaction is the exchange of information, influence, or energy between two agents within…) that can join Hfq protein and DNA (single or double stranded).

Two previous studies showed that the Hfq protein:
They form amyloid structures, such as those found in neurodegenerative diseases, and that these structures compromise the integrity of the bacterial membrane.
– Participate in control (The word control can have multiple meanings. It can be used as a synonym for control, or…) of the DNA solution flow. The amyloid (C-terminal) region of the Hfq protein is particularly involved in the reaction Mechanically (In everyday language, mechanics is the field of machines, engines, vehicles, organs, etc.) That liquid (The liquid is a fully deformable medium of matter. Below we collect…) Connection, formation (In intonation, fundamental frequency changes are viewed as differences in….) “Soft” heterogeneous body.

These initial results were followed by a new structural study showing for the first time that the amyloid region of Hfq drastically alters the structure of single-stranded DNA by forming Snail (The propeller comes from a Greek word helix, meaning “spiral”. A shaped body…) In parallel, causes alignment of the Hfq:DNA complex.

To get this result a Mix (could be plural 🙂 Experimental methods including spectroscopy (ring and linear dichroism on synchrotron and infrared) and molecular imaging (fluorescence and microscopy (Microscopic examination is the observation of a specimen (placed in a microscopic slide…) electron) to study interactions between Hfq and single-stranded DNA and the formed nucleoprotein complexes.


Different views of the Hfq protein molecular representation: The molecular surface of the N-terminal domain is gray and shown Green colour (Green is a complementary color that corresponds to one wavelength of light…). Beta sheets (blue) and alpha helices (red) appear as a ribbon in the monomer. Due to an unknown structure, the C-terminal amyloid region is missing here.

The action of the Hfq protein on the highlighted DNA has important implications for DNA replication and recombination. Experienced.

Hence, single-stranded DNA-binding Hfq proteins play critical roles in many fundamental biological processes, including DNA replication and recombination. hereditary (Genetics (from Greek genno γεννώ = birth) is…). Hfq is also a file actor (An actor is an artist who impersonates a character in a film, in a play, in….) Important in controlling bacterial chromosome structure and gene expression. to organize (Regulation in the concrete sense describes a technical system that is…) The possibility of reproduction and recombination that can occur in all living cells.

Relation:
The interaction of amyloid-like Hfq with single-stranded DNA: involvement in recombination and replication in Escherichia coli,
Krzysztof Kubiak, Frank Wien, Indresh Yadav, Nykola C. Jones, Søren Vrønning Hoffmann, Eric Le Cam, Antoine Cossa, Frederic Geinguenaud, Johan RC van der Maarel, Grzegorz Węgrzyn, and Véronique Arluison appear in Biophysics Quarterly Reviews.

Cooperation:
university (The university is a college whose aim is…) Paris Saclay Laboratory Leon Brillouin (Léon Brillouin (born August 7, 1889 in Sèvres – died 1969 in New York) was a physicist…) UMR CEA-CNRS, LLB / MMB
– Disco beamline, synchrotron The sun (The Sun (Sol in Latin, Helios or Ήλιος in Greek) is the Star…)
– ISA Synchrotron (Aarhus Denmark) and the Faculty of Physics and Astronomy at Aarhus University
– CNanoMat and Inserm platform, U1148, Vascular Transfusion Laboratory Science (According to the dictionary, science (lat. science, “knowledge”) is …)UFR SMBHAnd the University of Paris 13 (University of Paris 13 (official name: Paris-XIII) is a university…)And the Sorbonne Paris City (Sorbonne Paris City is a Center for Research and Higher Education (PRES)…)And Bobigny University
– Institute of Molecular Biology, University of Gdańsk (Poland),
– Department of Physics, National University of Singapore
– genome integrity and Cancer (Cancer is a disease characterized by abnormal cell proliferation…)And the institute (An institute is a permanent organization created for a specific purpose. It is…) Gustave Rossi (Gustave Rossi was born in Vevey (Switzerland) on November 24, 1874 and died in …)
Korean Institute (Korean Institute is an institution, its main activities on the one hand…)PSL University, Paris-Saclay University, CNRS (The National Center for Scientific Research, better known by the acronym CNRS, is the largest…) UMS2016, Inserm US43, Multimedia Imaging Center.

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