NASA Spaceline Current Awareness List # 956 July 2, 2021 (Space Life Science Research Results)

NASA Spaceline Current Awareness List # 956 July 2, 2021 (Space Life Science Research Results)

Status report from: Spaceline
Posted: Friday July 2nd, 2021

Papers obtained from NASA support:

1

Stahl-Rommel S, Li D, Sung M, Li R, Vijayakumar A, Atabay KD, Bushkin GG, Castro CL, Foley KD, Copeland DS, Castro-Wallace SL, Alvarez Saavedra E, Gleason EJ, Kraves S.

A CRISPR-based assay to study eukaryotic DNA repair aboard the International Space Station.

Plus one. June 30, 2021; 16 (6): e0253403.

Journal Impact Factor: 2,740

Financing: “This study was funded by miniPCR bio and Boeing.” Sarah L. Castro-Wallace is affiliated with the NASA Johnson Space Center.

2

Desai RI, Kangas BD, Limoli CL.

Nonhuman Primate Models in the Study of Space Stressors: Past Posts and Future Directions.

Life Science Space Res. 2021 Aug. 30: 9-23. Review.

Note: From the summary: “This overview is structured in such a way that it: a) Provides an overarching overview of the previous contributions by NHPs [nonhuman primates] space research as well as the strengths, limits and translational value of NHP research per se and in the existing context of NASA-relevant rodent research; b) highlight specific conclusions based on published literature and areas needed for future efforts; c) Describe critical research gaps and priorities in NHP research to facilitate NASA efforts to address key knowledge gaps that currently exist in the transfer of rodent data to humans; and d) provide a roadmap of recommendations to NASA regarding the availability, validity, strengths, and limitations of various NHP models for future targeted research.

Journal Impact Factor: 2,453

Financing: “This work was supported by contract TXS0147017, awarded to the KBRwyle / National Aeronautics and Space Administration (NASA) first author, NASA Johnson Space Center.”

3

Morrison MD, Thissen JB, Karouia F, Mehta S, Urbaniak C, Venkateswaran K, Smith DJ, Jaing C.

Investigation of space-induced changes in the microbiome of astronauts.

Microbiol. June 02, 2021; 12: 659179.

PIs: K. Venkateswaran, C. Jaing, C. Urbaniak, NASA Postdoctoral Fellowship

Note: ISS results. This article can be obtained online free of charge.

Journal Impact Factor: 4,235

Financing: “MM, JT, and CJ were funded by NASA Space Biology under Contract No. 80NSSC18K0113. Some of the research described in this publication was conducted at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This research was carried out Funded by 2014 Space Biology NNH14ZTT002N Grant No. 19-12829-38 under Task Order NNN13D111T Award to KV, which also partially funded a postdoctoral fellowship for CU funded by NASA Space Biology under Contract Number: 80NSSC18K0113 DS was funded by NASA Ames Space Biology Program FK was supported by the KBRwyle / FILMSS subcontract with the Department of Pharmaceutical Chemistry at the University of California, San Francisco, # NNA14AB82C at NASA’s Ames Research Center. Funders played no role in study design, data collection and analysis, the decision to publish or prepare the manuscript. “

4th

Greenwald SH, Macias BR, Lee SMC, Marshall-Goebel K, Ebert DJ, Liu JHK, Ploutz-Snyder RJ, Alferova IV, Dulchavsky SA, Hargens AR, Stenger MB, Laurie SS.

The intraocular pressure and the choroidal thickness react differently to the lower body negative pressure during space travel.

J. Appl. Physiol. (1985). 2021 June 24th. Online before printing.

PIs: SA Dulchavsky, AR Hargens, MB Stenger

Note: ISS results. From abstract: “Spaceflight-associated neuro-ocular syndrome (SANS) develops during prolonged (> 1 month) space travel, presumably due to chronic exposure to head fluid displacement that occurs in weightlessness. We wanted to see if there was a reversal This fluid displacement towards the head “with acute application of lower body negative pressure (LBNP) can influence the result measurements on the eye.”

Journal Impact Factor: 3,044

Financing: “Supported by NASA’s Human Research Program grants NNJ11ZSA002NA (MBS), NNX13AK30G (SAD), and NNX13AJ12G (ARH).”

5

Salazar AP, Hupfeld KE, Lee JK, Banker LA, Tays GD, Beltran NE, Kofman IS, De Dios YE, Mulder E, Bloomberg JJ, Mulavara AP, Seidler RD.

The brain’s visuomotor adaptation changes during a space flight analog with increased carbon dioxide (CO₂): A pilot study.

Front neural circuits. June 7, 2021, 15: 659557.

PI: RD Seidler

Journal Impact Factor: 3,156

Financing: “This work was supported by grants from the National Aeronautics and Space Administration (NASA; NNX11AR02G and 80NSSC17K0021) to RS, AM, and JB. In addition, while this work was being completed, KH was supported by a graduate research project from the National Science Foundation (NSF) Grant nos. DGE-1315138 and DGE-1842473, National Institute of Neurological Disorders and Stroke (NINDS) Training Grant T32-NS082128 and National Institute on Aging Fellowship 1F99AG068440. “

6th

Brown LS, St. Hilaire MA, McHill AW, Phillips AJK, Barger LK, Sano A, Czeisler CA, Doyle FJ 3^approx, Klermann EB.

A classification approach to estimate the human circadian phase under circadian alignment from actigraphy and photometric data.

J Pineal Res. May 29, 2021: e12745. Online before printing.

PI: MA St. Hilaire

Journal Impact Factor: 14,528

Financing: “National Institutes of Health, Grant / Award Number: T32-HL007901, R01GM105018, R00HL119618, K24HL105664, K01HL146992, P01AG009975, F32DK107146, and R21-NR018974 Corporation; Harvard Catalyst and NIH, Grant / Award Number: 1UL1TRendien-001; Administration; / Price number: 80NSSC20K0576; MIT Media Lab; Samsung. “

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Other interesting papers:

1

Hayashi T, Kudo T, Fujita R, Fujita SI, Tsubouchi H, Fuseya S, Suzuki R, Hamada M, Okada R, Muratani M, Shiba D, Suzuki T, Warabi E, Yamamoto M, Takahashi S.

A lack of nuclear factor E2-related factor 2 (NRF2) accelerates the rapid transition of the fiber type in the soleus muscle during space travel.

Komm. Biol. June 24, 2021; 4 (1): 787.

Note: ISS results. From the introduction: “In the current study, we used Nrf2 knockout (KO) mice to investigate the direct role of NRF2 in soleus muscle adaptation during FL [flight]. We introduced the Mouse Habitat Unit (MHU) to launch and manage genetically modified animals in space using advanced technology. The results show that soleus muscle mass as well as the size of each fiber type decreased at a rate almost identical between wild type (WT) and knockout mice after FL. “This article is available online for free.

2

Belyaeva AG, Kudrin VS, Koshlan IV, Koshlan NA, Isakova MD, Bogdanova YV, Timoshenko GN, Krasavin EA, Blokhina TM, Yashkina EI, Osipov AN, Nosovsky AN, Perevezentsev AA, Shtemberg AS.

Effects of combined exposure to modeled radiation and gravitational factors of interplanetary flight: cognitive functions of monkeys and the content of monoamines and their metabolites; cytogenetic changes in peripheral blood lymphocytes.

Life Science Space Res. 2021 Aug. 30: 45-54.

Note: A 7 day anti-orthostatic hypokinesia was used in this study.

3

Kaschubek D.

Optimized composition of the plant growth area for long-term flights.

Life Science Space Res. August 2021; 30: 55-65.

Note: From the abstract: “This paper presents an optimized composition of plant growth areas for biological life support systems in terms of nutrition and equivalent system mass. For this purpose, plant growth area compositions from the literature are compared with compositions derived from an optimization algorithm. The optimization algorithm uses literature data for plant growth rates and the nutritional content of the plants to minimize the required plant growth area required to provide all of the nutrients to a human. “

4th

Wu X, Yin Y, Liu J, Zhu Y, Fan Q, Zhao S, Wang J, Gao J, Liu Y, Jiao L, Li Y.

Baoyuan Jieyu Formula improves depression-like behavior in rats, which is triggered by simulated long-term composite stress in space travel by regulating the MAPK and BDNF pathways.

Life Science Space Res. June 6, 2021. Online before printing.