Increasing research and development, advances in genomics, and a growing awareness of the benefits of whole exome sequencing are some key factors that will drive market growth
Whole exome sequencing is a widely used and important next-generation sequencing technique that efficiently sequences all of the protein-coding regions in a genome. Whole exome sequencing is mainly used to screen and identify variations and mutations in the protein coding regions. Sequencing the entire exome can accurately identify genetic mutations associated with birth defects and developmental delays. A growing awareness of the benefits of whole exome sequencing in detecting genetic disorders, increasing investments to accelerate genome and proteomics research, and the adoption of cutting-edge technologies are key factors expected to drive market sales growth over the forecast period.
Whole exome sequencing is a genomic technique that sequences all of the protein-coding regions in a genome by selecting a subset of DNA that encodes proteins and then sequencing the exonic DNA through high-throughput technology of DNA sequencing. Whole exome sequencing aims to identify genetic variants that alter protein sequences and has been widely used in academic research and as a clinical diagnostic tool. Whole exome sequencing is increasingly used to complement other genetic tests, to find mutations in genes known to cause disease, and to identify new genes by comparing exomes from patients with similar characteristics. Sequencing the entire exome has proven to be an effective tool for discovering genetic defects in patients with primary immunodeficiency. It is also a powerful tool for the molecular diagnosis of rare monogenic diseases, the identification of de novo variants in complex diseases, and tumor analysis to identify genes responsible for cancer.
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Whole genome sequencing is increasingly cost effective compared to whole genome sequencing and is used extensively to identify gene mutations in the underlying disease, to make informed diagnostic and therapeutic decisions, and to treat family members at risk. Extensive research is being carried out to understand the application of full exome sequencing in the discovery of rare gene variants and this is expected to continue to drive sales growth of the market. However, ethical issues related to this technique, the lack of skilled labor, and concerns about the sensitivity of exome sequencing may hinder its adoption and slow market growth over the forecast period.
COVID-19 impact analysis
- The virus outbreak and social distancing norms and restrictions have seriously disrupted the entire business landscape and operations around the world.
- The COVID-19 pandemic and lockdowns have resulted in several countries closing airports, ports, and commercial and domestic transportation. This had had an impact on production activities and operations around the world and had a negative impact on the economies of various countries.
- The sudden and sharp downturn in economic activity slowed manufacturing, production, import / export and other sectors, and also resulted in significant job losses.
- The impact on supply was compounded by challenges on the demand side from lower disposable income, depletion of savings, and mounting concerns and uncertainties.
- The emergence of variants of the virus and the rise in infection rates during the first waves and subsequent lockdowns have severely impacted operations and disrupted supply chains.
Service segment for the largest share of sales:
The Services segment will account for the largest share of sales in the forecast period due to the increasing demand for data analysis services with high throughput. Data analysis and NGS services cover a wide range of services, from experimental design to library creation, to help researchers and scientists overcome the limitations of bioinformatic problems and save time and reduce costs.
Post-Synthesis Sequencing to Register a Rapid Turnover CAGR:
Post-synthesis sequencing is expected to improve in the forecast period due to the increasing adoption of this method for whole exome synthesis due to its advantages such as accurate sequencing from base to base, accurate data for different applications, minimal errors, and reduced likelihood of repeated nucleotides.
Personalized medicine segment records significant sales growth:
The Personalized Medicine segment is expected to dominate other application segments in terms of revenue growth driven by the growing need for tailored therapeutic approaches for chronic and rare diseases, the rapid advancement in genetic medicine, and the increasing use of whole exome sequencing in the development of advanced diagnostic tools and therapeutic approaches.
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North America with a significantly large share of sales:
North America is likely over the forecast period due to the growing focus on personalized medicine, increasing R&D activities in genomics and proteomics, increasing use of whole exome sequencing to detect rare genetic diseases, and robust presence of key market players.
The main companies in the market include:
- Illumina, Inc.
- Thermo Fisher Scientific, Inc.
- Agilent Technologies
- Hoffman-La Roche AG
- Eurofins Scientific Group
- GENEWIZ, Inc.
- Knom, Inc.
- Macrogen, Inc.
- Ambry Genetics Corp.
- Beijing Genomics Institute
For the purposes of this report, Emergen Research has segmented the global Exome Sequencing Market by product, application, technology, end-use, and region:
Product Outlook (Revenue, $ Mn; 2018-2028)
- DNA fragmentation end repair, A-tailing and size selection
- Library prep kits
- Target Enrichment Kits
- Sequencing services
- Data analysis services
Application Outlook (Revenue, $ Mn; 2018-2028)
- Monogenic disorders
- Drug research and development
- Personalized medicine
- Agriculture and Animal Research
Technology Outlook (Revenue, $ Mn; 2018-2028)
- Sequencing by synthesis
- Ion semiconductor sequencing
End-Use Outlook (Revenue, MILLION USD; 2018-2028)
- Academic Institutions & Research Centers
- Hospitals & clinics
- Pharmaceutical and biotechnology companies
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Regional Outlook (Revenue, MILLION USD; 2018-2028)
- North America
- Rest of Europe
- Asia Pacific
- South Korea
- Rest of APAC
- Latin America
- Middle East & Africa
- Saudi Arabia
- South Africa
- Rest of MEA
- Rest of MEA
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